Translational Oncologic Imaging

Cardiovascular Imaging Group

Radiologische Forschung (Radiology Research)

Muskuloskelettale Radiologie (Musculoskeletal Radiology)

Molekulare Bildgebung (Molecular imaging)

 

 

AG Rasper & Nadjiri

Cardiovascular Imaging Group

Contact Details

 M. Rasper, J. NadjiriMichael Rasper, MD
Jonathan Nadjiri, MD

Department of Diagnostic and Interventional Radiology
Technische Universität München
Klinikum rechts der Isar
Ismaningerstr. 22, 81675 München

phone: +49 (0) 89 4140 9603
email:
michael.rasper(at)tum.de
jonathan.nadjiri(at)tum.de

Research Profile

Cardiovascular imaging is one of the mainstays of modern cardiovascular diagnostics. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) allow for the detection of a broad spectrum of diseases of the coronary vessels and the myocardium itself.

The main focus of our group is to improve existing cross-sectional imaging techniques and to establish new imaging approaches in cardiovascular diseases. One of the core themes is research in the field of spectral-CT for coronary artery assessment. This new technique allows for a significant reduction of the amount of iodine containing contrast agent needed for coronary angiography. Moreover, our group investigates the use of alternative contrast agents like Gadolinium for detection of cardiovascular pathologies such as coronary vessel disease in combination with spectral-CT technique.

The group works on advanced MRI sequence techniques such as myocardial T1 and T2 mapping. These sequences allow for an objective characterization of myocardial structure. Our goal is to establish new and shortened MRI protocols based on functional and mapping sequences to rule out specific cardiac pathologies like inflammatory changes of the myocardium without the need to administer gadolinium-based contrast agents.

The group investigates new sequence techniques for characterization and follow-up of aortic aneurysms, under them 4D angiographies and 4D flow sequences. Moreover, new imaging approaches for characterization of coronary and carotid plaques are investigated in close cooperation with the Department of Cardiology (Head: Prof. Dr. K.-L. Laugwitz), the Department of Vascular Surgery (Head: Prof. Dr. H.H. Eckstein), the AG Pfeiffer and the AG Carampinos.

Group Members

Michael Rasper, MD

Jonathan Nadjiri, MD

Maximilian Englmaier, MD

Felix Meurer, MD

Alexandra S. Sträter, MD (currently on a research stay in Rochester, USA)

Jannis Bodden, MD

Collaborators

AG Karampinos

AG Pfeiffer

Publications

Evaluation of a shortened cardiac MRI protocol for left ventricular examinations: diagnostic performance of T1-mapping and myocardial function analysis.
Nadjiri J, Zaschka AL, Straeter AS, Sauter A, Englmaier M, Weis F, Laugwitz KL, Rummeny EJ, Pfeiffer D and Rasper M. BMC Medical Imaging 2019; 19(57)

Accuracy of Calcium Scoring calculated from contrast-enhanced Coronary Computed Tomography Angiography using a dual-layer spectral CT: A comparison of Calcium Scoring from real and virtual non-contrast data.
Nadjiri J, Kaissis G, Meurer F, Weis F, Laugwitz KL, Straeter AS, Muenzel D, Noël PB, Rummeny EJ and Rasper M. PLOS ONE. 2018 Dec 6;13(12):e0208588.

Spectral Computed Tomography Angiography With a Gadolinium-based Contrast Agent: First Clinical Imaging Results in Cardiovascular Applications.  
Nadjiri J, Pfeiffer D, Straeter AS, Noël PB, Fingerle A, Eckstein HH, Laugwitz KL, Rummeny EJ, Braren R and Rasper M. (2018) J Thorac Imaging. 2018;33(4):246-253.

Long-Standing Cyanosis in Congenital Heart Disease Does not Cause Diffuse Myocardial Fibrosis.  
Kharabish A, Meierhofer C, Hadamitzky M, Nadjiri J, Martinoff S, Ewert P and Stern H. (2018). Pediatric cardiology; 39(1), 105-110.

Cardiac MOLLI T1 mapping at 3.0 T: comparison of patient-adaptive dual-source RF and conventional RF transmission.  
Rasper M, Nadjiri J, Sträter AS, Settles M, Laugwitz KL, Rummeny EJ and Huber AM. (2017). Int J Cardiovasc Imaging. Jun;33(6):889-897. doi: 10.1007/s10554-017-1072-8.

An FFR CT diagnostic strategy versus usual care in patients with suspected coronary artery disease planned for invasive coronary angiography at German sites: one-year results of a subgroup analysis of the PLATFORM (Prospective Longitudinal Trial of FFR CT: Outcome and Resource Impacts) study.  
Colleran R, Douglas P, Hadamitzky M, Gutberlet M, Lehmkuhl L, Foldyna B, Woinke M, Hink U, Nadjiri J, Wilk A, Wang F, Pontone G, Hlatky M, Rogers C and Byrne R. (2017). Open Heart, 4(1), e000526.

Automated Quantification of Coronary Plaque Volume From CT Angiography Improves CV Risk Prediction at Long-Term Follow-Up.  
Deseive S, Straub R, Kupke M, Nadjiri J, Broersen A, Kitslaar PH, Massberg S, Hadamitzky M and Hausleiter J. (2017). JACC: Cardiovascular Imaging.

3D non-contrast-enhanced ECG-gated MR angiography of the lower extremities with dual-source radiofrequency transmission at 3.0 T: Intraindividual comparison with contrast-enhanced MR angiography in PAOD patients.  
Rasper M, Wildgruber M, Settles M, Eckstein HH, Zimmermann A, Reeps C, Rummeny EJ and Huber AM. (2016). Eur Radiol. 26(9):2871-80.

Performance of native and contrast-enhanced T1 mapping to detect myocardial damage in patients with suspected myocarditis: a head-to-head comparison of different cardiovascular magnetic resonance techniques  
Nadjiri J, Nieberler H, Hendrich E, Will A, Greiser A, Martinoff S and Hadamitzky M. (2016). The international journal of cardiovascular imaging, 33(4), pp 539–547.

Prognostic value of T1-mapping in TAVR patients: extra-cellular volume as a possible predictor for peri- and post-TAVR adverse events  
Nadjiri J, Nieberler H, Hendrich E, Will A, Pellegrini C, Husser O, Hengstenberg C, Greiser A, Martinoff S and Hadamitzky M. (2016). The international journal of cardiovascular imaging, 32(11), pp 1625–1633.

T1-Mapping in Daily Cardiac Magnetic Resonance Imaging Practice: Combined Use of Native T1 and Extracellular Volume Quantification.  
Nadjiri J, Hendrich E, Will A, Pankalla C, Greiser A, Martinoff S and Hadamitzky M. (2016) International Journal of Cardiovascular Research, 5(3).

Incremental prognostic value of quantitative plaque assessment in coronary CT angiography during 5 years of follow up.  
Nadjiri J, Hausleiter J, Jähnichen C, Will, A, Hendrich E, Martinoff S and Hadamitzky M. (2016). Journal of cardiovascular computed tomography, 10(2), 97-104.

Prognostic value of coronary CT angiography in diabetic patients: a 5-year follow up study.  
Nadjiri J, Hausleiter J, Deseive S, Will A, Hendrich E, Martinoff S and Hadamitzky M. (2016). The international journal of cardiovascular imaging, 32(3), 483-491.

Dual-source RF transmission in cardiac SSFP imaging at 3 T: systematic spatial evaluation of image quality improvement compared to conventional RF transmission.  
Rasper M, Gramer BM, Settles M, Laugwitz KL, Ibrahim T, Rummeny EJ and Huber A. (2015). Clin Imaging. Mar-Apr;39(2):231-6.

Single-dose gadobutrol in comparison with single-dose gadobenate dimeglumine for magnetic resonance imaging of chronic myocardial infarction at 3 T  
Wildgruber M, Stadlbauer T, Rasper M, Hapfelmeier A, Zelger O, Eckstein HH, Halle M, Rummeny EJ and Huber AM. (2014). Invest Radiol. Nov;49(11):728-34.

Reproducibility of area at risk assessment in acute myocardial infarction by T1- and T2-mapping sequences in cardiac magnetic resonance imaging in comparison to Tc99m-sestamibi SPECT.  
Nadjiri J, Langhans B, Jähnichen C, Kastrati A, Martinoff S and Hadamitzky M. (2014). The International Journal of Cardiovascular Imaging, 30(7), 1357-1363.