Molekulare Bildgebung (Molecular imaging)

Muskuloskelettale Radiologie (Musculoskeletal Radiology)

Radiologische Forschung (Radiology Research)

 

 

Laboratory for Advanced Computed Tomography Imaging

Contact Details

Department of Diagnostic and Interventional Radiology
Technische Universität München
Klinikum rechts der Isar
Ismaningerstr. 22, 81675 München

phone: +49 (0) 89 4140 7220
email: peter.noel@tum.de

Mission

The "Laboratory for Advanced Computed Tomography Imaging" is dedicated to developing next generation x-ray and computed tomography solutions to make additional diagnostic and therapy information available that exceeds current clinical standards. When it comes to diagnostics and therapy monitoring, the current tendency is to look at simple ‘gray-values’ (representing attenuation) and contrast differences to determine whether anatomical or pathological changes have occurred. In order to extend current possibilities and limitations, several new approaches are under investigation in our Lab, namely spectral / photon-counting and phase-contrast / dark-field imaging. Both of these technologies promise to significantly extend current diagnostic possibilities; however, clinical standards, for example with respect to radiation exposure and acquisition speed, need to be maintained for future clinical systems.  To fulfill current clinical standardsnow and in the future, we are investigating new acquisition schemes (e.g. sparse sampling) in combination with advanced reconstruction algorithms. This type of approach is a central ingredient to our research: the harmonization between hardware and software, reconstruction as well as post processing, to achieve integrated clinical solutions. Our strong collaboration with experts in clinical departments and the medical device industry guides and accelerates the translation of new technologies into early clinical application.The "Laboratory for Advanced Computed Tomography Imaging" is located in the Institute for Diagnostic and Interventional Radiology at Klinikum rechts der Isar der Technischen Universität München. The lab is connected with the Chair of Biomedical Physics at TUM.

Group Members

PI

Peter B. Noël, PhD 
  
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Dr. Noël is currently member of the Institute for Diagnostic and Interventional Radiology and of the Chair of Biomedical Physics. He is the Principle Investigator of the "Laboratory for Advanced Computed Tomography Imaging" and of department-wide research related to Computed Tomography and X-ray imaging. For his undergraduate training Dr. Noël completed a degree in Biomedical Engineering at the University of Applied Sciences in Giessen, Germany. In 2004 he received a Masters degree in Biomedical Engineering from University of Applied Sciences in Giessen, Germany. While conducting research in the area of interventional imaging at the Toshiba Stroke Research Center (Buffalo, NY), he received a Masters degree in Computer Science. In 2009 he finalized his Ph.D. in Computer Science from SUNY at Buffalo with focus on advanced 3D reconstruction algorithms. Under his guidance the "Laboratory for Advanced Computed Tomography Imaging", which he established in 2010, has achieved highly recognized scientific results in the field of Computed Tomography. Currently his primary research interest is in the area of biomedical imaging and includes X-ray imaging, Computed Tomography, advanced reconstruction approaches, phase contrast & dark-field imaging, spectral imaging with photon counting detectors, imaging on micro / nano scale, high performance computing with GPUs and clinical translation of advanced technologies. Dr. Noël's research efforts are currently supported by national as well as industrial grants. His achievements in the area of radiation exposure for CT imaging were awarded with a research award from the Behnker-Berger foundation.


  
Clinical PIs
  
Daniela Münzel, MD, MHBA
  
 
  
  
  
  
  
  

PD Dr. Daniela Münzel is an attending at the Institute for Diagnostic and Interventional Radiology and senior scientist at the Chair of Biomedical Physics of the Technical University of Munich. She is the Clinical Principle Investigator of the "Laboratory for Advanced Computed Tomography Imaging". Dr. Münzel completed medical school at the University of Regensburg and received the Medical Doctor (MD) for her studies on molecular effects in diabetes. She finished residency with the board certificating of Radiology at the Klinikum rechts der Isar at TUM, followed by a clinical fellowship in musculoskeletal radiology. Beside practicing and refining her excellent knowledge in clinical radiology in day-to-day patient care, Dr. Münzel strongly engages in a number of research projects in Biomedical Imaging. Her main interests and most important scientific results lie in the field of photon counting CT technology, dual-energy and spectral CT applications, dark-field and phase contrast imaging, and machine learning in clinical applications. Dr. Münzel is internationally well recognized and has strong collaborations with several highly-recognized institutions, such as the Massachusetts General Hospital / Harvard Medical School (where she has been as a research fellow). Dr. Münzel has earned a masters degree in Business Health Administration, and she is also the head of quality management at the Department of Radiology, and a member of the subcommittee of audits and standards of the European Society of Radiology. With respect to teaching, she supervises Bachelor, Master and PhD students, and is engaged in several lectures as guest lecturer for special topics.


 

Alexander Fingerle, MD, MHBA
Alexander Fingerle
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Dr. Fingerle (b. 1978) is currently an attending radiologist at the Institute for Diagnostic and Interventional Radiology and a member of the Chair of Biomedical Physics. He is clinical principal investigator of the „Laboratory for Advanced Computed Tomography Imaging“. Dr. Fingerle attended medical school at the University of Ulm, Germany. In 2004 he started his medical career in the Department of Internal Medicine (Gastroenterology, Endocrinology, Diabetology, Infectiology) at the Klinikum rechts der Isar. In 2008 he continued his medical training at the Institute of Diagnostic and Interventional Radiology and completed his radiology residency in 2014. In 2016, Dr. Fingerle passed the european board examination in radiology (European Diploma in Radiology, EDiR) and obtained a master’s degree (Master of Health Business Administration, MHBA) from Friedrich-Alexander-Universität Erlangen-Nürnberg. Since 2015 he is an attending radiologist with a clinical focus on cancer imaging including PET/CT and MR-PET and musculoskeletal radiology. His research interests include advanced CT imaging techniques (Dual Layer Dual Energy CT, Photon Counting CT) and experimental phase-contrast and dark-field x-ray imaging.


  
Staff
   

Veronica Bodek (Project Management)

Melanie Kimm, PhD

Research Fellows

Julia Dangelmaier, MD

Alexandra Gersing, MD

Martin Renz, MD

Isabelle Riederer, MD

Andreas Sauter, MD

Benedikt Schwaiger, MD

PhD & MSc Students

Johannes Hammel (MSc student)

Stefanie Kaiser (MD Student)

Felix Kopp, MSc (PhD student)

Alexis Laugerette (MSc student)

Kai Mei, MSc (PhD student)

Manuel Schultheiß (PhD student)

Julia Fokuhl (MSc student)

Common PhD Students with Chair of Biomedical Physics


News

Peter Noël is now member of the scientific editorial board (Physics) of European Radiology  (Jan, 2018)

Dr. Muenzel is now a member of the Scientific Committee of the Radiological Society of North America (Nov, 2017)

Dr. Muenzel gives two oral presentations about latest results on Dual-Energy CT imaging at RSNA 2017 (Nov 26-29, 2017)

Dr. Münzel receives the Röntgen-Price, and presents a keynote lecture at the University of Giessen (Nov 24,2017)

Succesfull Hands-on Spectral CT Workshop (Nov 10, 2017)

Peter B. Noël has received funding form the DFG as a Co-PI of the The Research Training Group / Graduiertenkolleg GRK 2274 "Advanced Medical Physics for Image-guided Cancer Therapy" (July, 2017)

Editor’s pick of the Month (May) – Radiology June 2017: Spectral Photon-counting CT: Initial Experience with Dual–Contrast Agent K-Edge Colonography (May, 2017)

Felix Kopp and Peter Noël receive hardware grant from Nvidia for "Automated estimation of diagnostic image quality using Deep Learning" (Apr, 2017)

DI Europe: "CT Pulmonary Angiography (CTPA) as a sub-mSv modality" (Mar, 2017)

TUM: "Mini particle accelerator saves contrast media" (Feb 27, 2017)

RSNA 2016: "Dual-Contrast Photon-Counting CT Improves Diagnosis of Liver Lesions" (Dec, 2016) 

New spectral CT installed (Oct 6, 2016)

Die Zeit: "Strahlend im Verbund"  (Jul 21, 2016)

SPIE 2017: Dr. Noël elected to Conference Committee of "SPIE Medical Imaging Conference" (Mar, 2016)

TUM IAS: "Phase-Contrast Computed Tomography" (Jan 21, 2016)

TUM IdeAward zeichnet Ideen mit Marktpotenzial aus (Feb 20, 2015)

medtech zwo: "Telemedizin auf Traumschiff" (Jun 30, 2014)

RSNA Daily Bulletin (Wednesday, December 04, 2013)

Collaborators

Mats Danielsson, KTH Royal Institute of Technology, Stockholm, Sweden.

Philippe Douek, Claude Bernard University Lyon, Lyon, France.

Torsten Enßlin, Max-Planck-Institut für Astrophysik, München, Germany

Martin Fiebich, Institut für Medizinische Physik und Strahlenschutz, Technische Hochschule Mittelhessen, Giessen, Germany.

Zeng Zu Jin, Peking Union Medical College, Beijing, P. R. China.

J. Webster Stayman, Johns Hopkins University, Baltimore, United States.

Dushyant Sahani, Massachusetts General Hospital, Harvard University, Boston, United States.

Hiroyuki Yoshida, Massachusetts General Hospital, Harvard University, Boston, United States.

Open Positions

We are always looking for highly skilled and highly motivated individuals to add to the research team. Please do send us an email. However, please include a CV and take a moment to read a few of our publications and let us know specifically what you find interesting and how your skills would contribute. Thanks!

Teaching

Medical Imaging Technology

Grant support

Logo of DFG Deutsche Forschungsgemeinschaft
Logo of NVIDIA Corporation

 

Publications

2018

Braig, E. M., Birnbacher, L., Schaff, F., Gromann, L., Fingerle, A., Herzen, J., Rummeny, E.J., Noël, P., Pfeiffer, F. & Muenzel, D. (2018). Simultaneous wood and metal particle detection on dark-field radiography. European Radiology Experimental, 2(1), 1

Noël, P. B., Engels, S., Köhler, T., Muenzel, D., Franz, D., Rasper, M., Rummeny, E.J., Dobritz, M. & Fingerle, A. A. (2018). Evaluation of an iterative model-based CT reconstruction algorithm by intra-patient comparison of standard and ultra-low-dose examinations. Acta Radiologica, 0284185117752551

Mookiah, M. R. K., Rohrmeier, A., Dieckmeyer, M., Mei, K., Kopp, F. K., Noel, P. B., Kirschke, J.S., Baum, T. & Subburaj, K. (2018). Feasibility of opportunistic osteoporosis screening in routine contrast-enhanced multi detector computed tomography (MDCT) using texture analysis. Osteoporosis International, 1-11

2017

Muenzel, D., Daerr, H., Proksa, R., Fingerle, A. A., Kopp, F. K., Douek, P., Herzen, J., Pfeiffer, F., Rummeny, E.J. & Noël, P. B. (2017). Simultaneous dual-contrast multi-phase liver imaging using spectral photon-counting computed tomography: a proof-of-concept study. European Radiology Experimental, 1(1), 25.

Ehn, S., Sellerer, T., Muenzel, D., Fingerle, A. A., Kopp, F., Duda, M., Mei, K., Renger, B.,Herzen, J., Dangelmaier, J., Schwaiger, B. J., Sauter, A., Riederer, I., Renz, M., Braren, R., Rummeny, E.J., Pfeiffer, F. & Noël, P.B. (2017). Assessment of quantification accuracy and image quality of a full‐body dual‐layer spectral CT system. Journal of applied clinical medical physics.

Mei, K., Schwaiger, B. J., Kopp, F. K., Ehn, S., Gersing, A. S., Kirschke, J. S., Muenzel, D., Fingerle, A.A., Rummeny, E.J., Pfeiffer, F., Baum, T. & Noël, P.B.  (2017). Bone mineral density measurements in vertebral specimens and phantoms using dual-layer spectral computed tomography. Scientific Reports, 7(1), 17519

Jud, C., Braig, E., Dierolf, M., Eggl, E., Günther, B., Achterhold, K., Gleich, B., Rummeny, E., Noël, P., Pfeiffer, F. and Muenzel, D. (2017). Trabecular bone anisotropy imaging with a compact laser-undulator synchrotron x-ray source. Scientific reports, 7(1), 14477.

Marschner, M., Birnbacher, L., Willner, M., Chabior, M., Herzen, J., Noël, P. B., & Pfeiffer, F. (2017). Revising the lower statistical limit of x-ray grating-based phase-contrast computed tomography. PloS one, 12(9): e0184217.

Gromann, L. B., De Marco, F., Willer, K., Noël, P. B., Scherer, K., Renger, B., ... & Herzen, J. (2017). In-vivo X-ray Dark-Field Chest Radiography of a Pig. Scientific Reports, 7.

Mechlem, K., Ehn, S., Sellerer, T., Braig, E., Münzel, D., Pfeiffer, F., & Noël, P. B. (2017). Joint statistical iterative material image reconstruction for spectral computed tomography using a semi-empirical forward model. IEEE Transactions on Medical Imaging.

von Teuffenbach, M., Koehler, T., Fehringer, A., Viermetz, M., Brendel, B., Herzen, J., ... & Noël, P. B. (2017). Grating-based phase-contrast and dark-field computed tomography: a single-shot method. Scientific Reports, 7.

Mei, K., Kopp, F.K., Bippus, R., Köhler, T., Schwaiger, B.J., Gersing, A.S., Fehringer, A., Sauter, A., Münzel, D., Pfeiffer, F. and Rummeny, E.J., (2017). Is multidetector CT-based bone mineral density and quantitative bone microstructure assessment at the spine still feasible using ultra-low tube current and sparse sampling?. European radiology, 1-11.

Mookiah, M.R., Baum. T., Mei, K., Kopp. F.K., Foehr, P., Noël, P.B., Kirschke, J.S., Subburaj, K. (2017). Effect of radiation dose reduction on texture measures of trabecular bone microstructure: an in vitro study.J Bone Miner Metab.DOI 10.1007/s00774-017-0836-5

Mechlem, K., Allner, S., Ehn, S., Mei, K., Braig, E., Münzel, D., ...& Noël, P. B. (2017). A post-processing algorithm for spectral CT material selective images using learned dictionaries. Biomedical Physics & Engineering Express, 3(2), 025009.

Bronger, H., Hederich, P., Hapfelmeier, A., Metz, S., Noël, P. B., Kiechle, M., & Schmalfeldt, B. (2017).Sarcopenia in Advanced Serous Ovarian Cancer. International Journal of Gynecological Cancer, 27(2), 223-232.

Eggl, E., Mechlem, K., Braig, E., Kulpe, S., Dierolf, M., Günther, B., ...Noël, P., ... Muenzel, D. (2017). Mono-Energy Coronary Angiography with a Compact Synchrotron Source. Scientific Reports, 7, 42211.

Muenzel, D., Fingerle, A. A., Zahel, T., Sauter, A., Vlassenbroek, A., Dobritz, M., ...& Noël, P. B. (2017). CT Angiography: Post-processed Contrast Enhancement for Improved Detection of Pulmonary Embolism. Academic Radiology, 24(2), 131-136.

Richter, V., Willner, M. S., Henningsen, J., Birnbacher, L., Marschner, M., Herzen, J., Noël, P. B ...& Fingerle, A. A. (2017). Ex vivo characterization of pathologic fluids with quantitative phase-contrast computed tomography. European Journal of Radiology, 86, 99-104.

Enders, C., Braig, E. M., Scherer, K., Werner, J. U., Lang, G. K., Lang, G. E., Noël, P. B ... & Herzen, J. (2017). Advanced Non-Destructive Ocular Visualization Methods by Improved X-Ray Imaging Techniques. PLOS ONE, 12(1), e0170633.

Schröter, T. J., Koch, F. J., Meyer, P., Kunka, D., Meiser, J., Willer, K., Noël, P.B. ...& Yaroshenko, A. (2017). Large field-of-view tiled grating structures for X-ray phase-contrast imaging. Review of Scientific Instruments, 88(1), 015104.

Feußner, H., Hüser, N., Wilhelm, D., Fingerle, A., Jell, A., Friess, H., & Bajbouj, M. (2017).Surgical treatment of esophageal diverticula: Endoscopic or open approach?. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen,88(3):196-203

2016

Ehn, S., Sellerer, T., Mechlem, K., Fehringer, A., Epple, M., Herzen, J., ... & Noël, P. B. (2016). Basis material decomposition in spectral CT using a semi-empirical, polychromatic adaption of the Beer–Lambert model. Physics in Medicine and Biology, 62(1), N1.

Muenzel, D., Bar-Ness, D., Roessl, E., Blevis, I., Bartels, M., Fingerle, A. A., ... Noël, P. B. (2016). Spectral Photon-counting CT: Initial Experience with Dual–Contrast Agent K-Edge Colonography. Radiology, 160890.

Marschner, M., Birnbacher, L., Mechlem, K., Noichl, W., Fehringer, A., Willner, M., Noël, P. B.... & Pfeiffer, F. (2016). Two-shot X-ray dark-field imaging. Optics Express, 24(23), 27032-27045.

Bohrer, E., Schäfer, S., Mäder, U., Noël, P. B., Krombach, G. A., & Fiebich, M. (2016).Optimizing radiation exposure for CT localizer radiographs. Zeitschrift für Medizinische Physik. .

Sauter, A., Koehler, T., Fingerle, A. A., Brendel, B., Richter, V., Rasper, M., Noël, P. B ...& Münzel, D. (2016). Ultra low dose CT pulmonary angiography with iterative reconstruction. PloS one, 11(9), e0162716.

Kopp, F. K., Holzapfel, K., Baum, T., Nasirudin, R. A., Mei, K., Garcia, E. G., ...& Noël, P. B. (2016). Effect of Low-Dose MDCT and Iterative Reconstruction on Trabecular Bone Microstructure Assessment. PloS one, 11(7), e0159903.

Renger, B., Brieskorn, C., Toth, V., Mentrup, D., Jockel, S., Lohöfer, F., ...& Noël, P. B. (2016). Evaluation of dose reduction potentials of a novel scatter correction software for bedside chest X-ray imaging. Radiation protection dosimetry, 169(1-4), 60-67.

Allner, S., Koehler, T., Fehringer, A., Birnbacher, L., Willner, M., Pfeiffer, F., & Noël, P. B. (2016).Bilateral filtering using the full noise covariance matrix applied to x-ray phase-contrast computed tomography. Physics in medicine and biology, 61(10), 3867.

Ehn, S., Epple, F. M., Fehringer, A., Pennicard, D., Graafsma, H., Noël, P. B., & Pfeiffer, F. (2016). X-ray deconvolution microscopy. Biomedical Optics Express, 7(4), 1227-1239.

Willner, M., Viermetz, M., Marschner, M., Scherer, K., Braun, C., Fingerle, A., Noël, P. B.... & Herzen, J. (2016). Quantitative Three-Dimensional Imaging of Lipid, Protein, and Water Contents via X-Ray Phase-Contrast Tomography. PloS one, 11(3), e0151889.

Anitha, D., Subburaj, K., Mei, K., Kopp, F. K., Foehr, P., Noël, P. B., ... & Baum, T. (2016). Effects of dose reduction on bone strength prediction using finite element analysis. Scientific Reports, 6.

Marschner, M., Willner, M., Potdevin, G., Fehringer, A., Noël, P. B., Pfeiffer, F., & Herzen, J. (2016).Helical X-ray phase-contrast computed tomography without phase stepping. Scientific reports, 6.

Fischer, A., Lasser, T., Schrapp, M., Stephan, J., & Noël, P. B. (2016).Object Specific Trajectory Optimization for Industrial X-ray Computed Tomography. Scientific reports, 6.

Brendel, B., Teuffenbach, M., Noël, P. B., Pfeiffer, F., & Koehler, T. (2016).Penalized maximum likelihood reconstruction for x‐ray differential phase‐contrast tomography. Medical physics, 43(1), 188-194.

All publications...

Conference Proceedings